Sonnet biotherapeutics reports encouraging data from phase 1b/2a clinical trial of son-080 in chemotherapy-induced peripheral neuropathy (cipn) that support advancement into phase 2 study

Princeton, n.j., july 24, 2024 (globe newswire) -- sonnet biotherapeutics holdings, inc. (the “company” or “sonnet”) (nasdaq:sonn), a clinical-stage company developing targeted immunotherapeutic drugs, today announced encouraging data from the phase 1b portion of its phase 1b/2a clinical trial evaluating son-080 for the treatment of cipn (the “sb211 study”). the sb211 study is a double-blind, randomized, controlled trial of son-080 conducted at two sites in australia in patients with persistent cipn using a new proprietary version of recombinant human interleukin-6 (rhil-6) that builds upon previous work with atexakin alfa. the goal of the phase 1b portion of the sb211 study was to confirm safety and tolerability before continued development in phase 2. as previously announced in march 2024, a data and safety monitoring board reviewed the unblinded safety and tolerability of son-080 in the first nine patients and concluded that the symptoms were tolerable in the initial patients and the study could proceed to phase 2. additionally, the company participated in a virtual investor “what this means” segment to further discuss the phase 1b data and highlight what this means for its development program moving forward. click here to access the segment.
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