Panbela announces publication of abstract titled: evaluation of myeloma cell lines viability following administration of sbp-101 and dfmo polyamine inhibitors

Minneapolis, dec. 04, 2023 (globe newswire) --   panbela therapeutics, inc. (nasdaq: pbla), a clinical stage company developing disruptive therapeutics for the treatment of patients with urgent unmet medical needs, today announces the publication of preclinical data from studies of ivospemin (also known as sbp-101) and eflornithine (also known as cpp-1x or dfmo) research in multiple myeloma (cell lines). data published in the november supplemental issue of the journal blood investigated the effects of polyamine inhibition by ivospemin and cpp-1x on myeloma cell lines growth and viability in vitro. results showed that ivospemin and cpp-1x treatment significantly decreased cell proliferation and induced apoptosis in a panel of multiple myeloma cell lines. when ivospemin and cpp-1x were combined an almost complete abolition of cell growth occurred. these results demonstrate the anti-neoplastic potential of ivospemin and cpp-1x and offer a compelling rationale for its clinical development as a potentially promising treatment option for multiple myeloma.
PBLA Ratings Summary
PBLA Quant Ranking