Karyopharm therapeutics inc. selects amerisourcebergen corporation to support xpovio

Amerisourcebergen announced that it has been selected by karyopharm therapeutics inc. (karyopharm) to support xpovio(tm) (selinexor). amerisourcebergen is providing a unified commercialization approach for xpovio(tm), which was approved by the u.s. food and drug administration (fda) on july 3, 2019. xpovio(tm) is a nuclear export inhibitor indicated in combination with dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma (rrmm) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-cd38 monoclonal antibody. in the united states, there are 32,000 new cases of multiple myeloma, a cancer of plasma cells, each year. there are approximately 130,000 patients living with multiple myeloma in the united states today. the blood cancer is characterized by disease-related symptoms, including fatigue or weakness, unusual bleeding or bruising, and bone pain or fractures.3 patients who suffer from relapsed and refractory multiple myeloma have an average five to nine month survival rate depending on the number of prior lines of therapy.4 xpovio(tm) inhibits the function of a nuclear export protein called xpo1 and induces the accumulation of tumor suppressor proteins in the cell nucleus, leading to the selective death of cancer cells. amerisourcebergen's established expertise in supporting rare disease treatments helps ensure that critical medications are safely delivered from manufacturers to patients every day. amerisourcebergen is supporting xpovio(tm) through: specialty distribution: asd healthcare, one of the nation's largest specialty pharmaceutical distributors servicing 95% of u.s. hospitals, as well as specialty pharmacies, hemophilia centers, home healthcare companies and retail pharmacies, handles distribution services. oncology supply provides specialty distribution to independent oncology practices nationwide; gpo contracting for community oncology: amerisourcebergen provides gpo contracting, integrated dispensing solutions and expertise through ion solutions, the largest physician service organization and group purchasing organization specializing in the support of independent, community oncology practices; third-party logistics: ics, a pharmaceutical third-party logistics provider with 925,000 square feet of managed warehouse space across four strategic locations, aims to increase supply chain efficiency and ensure commercial success for selinexor. ics will support distribution to specialty pharmacies and distributors. ics was engaged two years prior to commercialization to support api storage and preparation for launch; dispensing: amerisourcebergen's specialty pharmacy us bioservices has more than two decades of experience supporting small patient populations and is dispensing xpovio(tm). the pharmacy also provides customized clinical care, focused on supporting adherence and patient outcomes. physicians may submit prescriptions for selinexor to us bioservices via phone (877.757.0667), fax (888.899.0067), eprescribe or the mypathpoint prescriber portal.
COR Ratings Summary
COR Quant Ranking