Biohaven provides update on taldefgrobep alfa development program for spinal muscular atrophy and obesity

In the resilient sma study, taldefgrobep alpha showed clinically meaningful improvements in motor function at all timepoints on the motor function measurement-32 scale (mfm-32), but the treatment arm did not statistically separate on the primary outcome at week 48 compared to the placebo+standard of care (soc) group. efficacy signals were observed in clinically relevant and biomarker-defined subgroups including those related to age, ambulatory status, background therapy, and baseline myostatin level.
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