Zyversa therapeutics announces published data supporting the rationale for inhibiting inflammasome asc with ic 100 to control chronic inflammation

Data demonstrate that extracellular asc specks, independent of il-1Β, govern the pathogenesis and extent of amyloid a (aa) amyloidosis, which is characterized by deposition of insoluble amyloid fibrils in tissues and organs disrupting their structure and function. extracellular asc interacts with serum amyloid a (saa) released by the liver during inflammation, forming a scaffold that accelerates saa aggregation into amyloid fibrils, which are deposited in tissues and organs.
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